Scombrotoxic fish poisoning
Scombroidea Scombrotoxic fish poisoning, also known as scombroid toxicity or scombrotoxic poisoning is a form of food poisoning. The mechanism of disease is debatable. One theory is that it is caused by histamine and histamine-like products, as a result of bacterial breakdown of seafood. Specifically, is thought that histidine is decarboxylated by This is supported by the finding that patients with scombrotoxic poisoning have elevated plasma and urinary histamine. On the other hand, the symptoms are not replicated with administration of oral histamine, which is not generally absorbed via the gut due to enzymatic degradation. It may be that another co-factor inhibits gut enzymatic degradation, allowing significant systemic absorption.
Foods notably associated with it are:
Symptoms come on within 2 minutes to 2 hours after eating the seafood.
- Rash and pruritus
- Diarrhoea and vomiting
- Flushing and sweating
- Burning or swelling of the mouth
- Abdominal pain
- Metallic taste
- ↑ Sattler J, Häfner D, Klotter HJ, Lorenz W, Wagner PK. Food-induced histaminosis as an epidemiological problem: plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). Agents and actions. 1988 Apr; 23(3-4):361-5.
- ↑ Morrow JD, Margolies GR, Rowland J, Roberts LJ. Evidence that histamine is the causative toxin of scombroid-fish poisoning. The New England journal of medicine. 1991 Mar 14; 324(11):716-20.(Link to article – subscription may be required.)