- Organ rejection prophylaxis in kidney allografts
Oral usually in range 2 to 6mg often adjusted with blood monitoring and taken diluted with water or orange juice
- Breast feeding
Cautions and Interactions
Multiple interactions some of considerable importance such as with cyclosporin
Multiple including hypersensitivity and immunosuppression
- Suppresses mTOR signaling by binding to a class of proteins actually first defined by its binding activity. It may thus be active from animal models in reducing malignant transformation in tuberous sclerosis and in prolonging life span. It inhibits:
Sirolimus binds to serine/threonine-protein kinase mTOR, a key regulatory kinase which results in inhibition at the G1 to the S phase of the cell cycle suppressing cytokine-driven T-cell proliferation.