Sweet's syndrome

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Sweet's syndrome (Sweet syndrome, acute febrile neutrophilic dermatosis) was first described by Sweet in 1964

  • Characterised by:
    • An acute neutrophilic dermatosis accompanied by pyrexia.
    • Debilitating well defined red or plum plaques or nodules. They may be pustular.
  • Aetiology is often unknown, but in such cases it is possible that the syndrome is due to a hypersensitivity reaction leading to cytokine-mediated neutrophil activation and infiltration as it can be induced by G-CSF.

Usually encountered in three main patient groups:

  • Those with malignancy (tumour-related or paraneoplastic)
  • Those on medication (drug-induced)
  • Those with no obvious cause (idiopathic or 'classic')


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