Talk:Hedgehog signalling pathway
From Ganfyd
Why "hedgehog"? --Penglish 11:20, 12 June 2007 (BST)
After Sonic the Hedgehog (computer game/cartoon character)as the fruit flies with a mutation develop pointy projections which resembled a hedgehog. See [1] Mark ong 12:11, 12 June 2007 (BST)I think a reference is needed before we are so sure of Marks claim. The pathway is claimed elsewhere to be named after the hedgehod (?hedgehog) gene in Drosophila which makes fruit fly larva spiky and as this was first described about 1988 [1] it may have predated Sonic. There was a fashion for naming segment polarity genes of fruit flies things like armadillo about then and I do not have a clue why some refs say hedgehod and some hedgehog, with hedgehog being the name for the hedgehod gene by 1992 according to a pubmed quick search[2].
Cheers Mlj 08:16, 13 June 2007 (BST)
- You might be right. I think the hedgehog (hod?) name was started before Sonic as Sonic is not the only member of the Hedgehog family of proteins. Wikipedia has a bit on discovery and origin of name. Mark ong
- my further pubmed search suggests sonic hedgehog was named in Dec 1993 in Cell as the mouse analogue. By then the renamed hedgehog gene pathways had started to be characterised in fruit flies[3][4] but GOKs when term pathway was used as not my field at all being a discovery after I left pure science behind Mlj 20:28, 13 June 2007 (BST)
- My biochemistry contact offers http://www.lbl.gov/Science-Articles/Archive/sb/Nov-2004/04-sonicthehedgehog.html on this and agrees with the pointy bits on fruit flies. Midgley 16:48, 16 June 2007 (BST)
- Further research reveals Sonic the Hedgehog only arrived in 1991 (June 23, 1991) Wikipedia:Sonic the Hedgehog(character) and Mark was getting confused with the Sonic hedgehog gene which was the third hedgehog gene to be described in mice.Mlj 21:57, 16 June 2007 (BST)
- My biochemistry contact offers http://www.lbl.gov/Science-Articles/Archive/sb/Nov-2004/04-sonicthehedgehog.html on this and agrees with the pointy bits on fruit flies. Midgley 16:48, 16 June 2007 (BST)
- my further pubmed search suggests sonic hedgehog was named in Dec 1993 in Cell as the mouse analogue. By then the renamed hedgehog gene pathways had started to be characterised in fruit flies[3][4] but GOKs when term pathway was used as not my field at all being a discovery after I left pure science behind Mlj 20:28, 13 June 2007 (BST)
References
- ↑ Mohler J. Requirements for hedgehod, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 1988;120(4):1061-72.
- ↑ Mohler J, Vani K. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development (Cambridge, England) 1992;115(4):957-71.
- ↑ Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993;75(7):1417-30.
- ↑ Riddle RD, Johnson RL, Laufer E, Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 1993;75(7):1401-16.
