Trihexyphenidyl

From Ganfyd

rINN: Trihexyphenidyl

Other Names

Benzhexol, Triexyphenidyl hydrochloride, Broflex^®

Pharmacological Information

Pharmacology Images

Trihexyphenidyl Molecule

Web information on Trihexyphenidyl

NHS Evidence on Trihexyphenidyl

DrugBank on Trihexyphenidyl

Relevant Clinical Literature

Pubmed on Trihexyphenidyl

RCT with Trihexyphenidyl

Systematic reviews of Trihexyphenidyl

Trihexyphenidyl in N Eng J Med, Lancet, JAMA, BMJ

Trihexyphenidyl in Cochrane Collaboration

TRIP Database on Trihexyphenidyl

Google Scholar on Trihexyphenidyl

Bandolier on Trihexyphenidyl

UK Guidance

SNOMED search

Nice Guidance on Trihexyphenidyl

BNF-registration required
BNF for children-registration required

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)

Prodigy Guidance on Trihexyphenidyl

Regulatory Literature

UK SPCs of medicines with marketing authorisation

EMEA search

FDA search

Other Literature

PubChem on Trihexyphenidyl

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Other Wikis

Medpedia on Trihexyphenidyl (Less technical, good quality control)

Wikipedia on Trihexyphenidyl (Less technical, ? quality control)

Introduction

Clinical Use

Indications

• Parkinsonism, particularly if drug induced

Administration

Oral

Clinical Issues

Contra-indications

Cautions and Interactions

Side effects

Anticholinergic so predictable side effects

Special advice

Try not to use in non drug induced progressive parkinsonism as CNS side-effects such as hallucinations and cognitive impairment tend to become problematical and withdrawal is difficult.

Pharmacology