Ulcer-associated cell lineage

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Photomicrograph of small bowel mucosa from a patient with Crohn's disease stained with AB/PAS. The upper glands are stained blue consistent with normal intestinal acid mucin. The three lower glands have neutral mucin (staining magenta) and correspond to the ulceration-associated cell lineage.

A cell line that develops in the gut in response to ulceration. Sometimes termed 'pyloric metaplasia'. It is thought to represent an epithelial regeneration pathway.[1][2] Its initial differentiation is similar to that of Brunner's glands, but its method of cell renewal resembles that of gastric mucosa.[3][4]

References

  1. ↑ Wright NA, Pike CM, Elia G. Ulceration induces a novel epidermal growth factor-secreting cell lineage in human gastrointestinal mucosa. Digestion. 1990; 46 Suppl 2:125-33.
  2. ↑ Wright NA, Pike C, Elia G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature. 1990 Jan 4; 343(6253):82-5.(Link to article – subscription may be required.)
  3. ↑ Ahnen DJ, Poulsom R, Stamp GW, Elia G, Pike C, Jeffery R, Longcroft J, Rio MC, Chambon P, Wright NA. The ulceration-associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland. The Journal of pathology. 1994 Aug; 173(4):317-26.(Link to article – subscription may be required.)
  4. ↑ Roberts IS, Stoddart RW. Ulcer-associated cell lineage ('pyloric metaplasia') in Crohn's disease: a lectin histochemical study. The Journal of pathology. 1993 Sep; 171(1):13-9.(Link to article – subscription may be required.)
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