User talk:Mlj

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Hi ! Is that another geriatrician ! Hope my fiddling with you work is up to standard.

Hi Mlj 22:48, 9 January 2006 (CET)


Tried editing the 65px height height as you suggested. The scrollbars came in at 82px. May be better to code at 85px. Good luck and thanksCiaran 00:31, 6 February 2006 (CET)

"Propanolol" is misspelled; correct is propRanololCiaran 23:59, 16 February 2006 (CET)

Contents

Account upgraded to Sysop + Beaurocrat

Hi, As you are so active it would probably make life much easier for you if you could delete pages as well, so now you can (Special:Specialpages). Also you can edit protected pages. Hope that is helpful. :-) --A.l.brown 11:50, 13 February 2006 (CET)

Internet resources page

Hi, Mlj!

I've left a comment for you at Talk:Internet resources - it reads as rather snooty, didn't mean it to be - sorry. --Penglish 19:32, 2 January 2006 (CET)

With reference to your comments on Talk:1949, it's hardly a disaster that a mistake was made, although well done for finding it, and for changing the links from 1949 to 1948. It seems to me that you've found them all, or perhaps the only one. For future reference, you can conveniently move pages rather than having to copy text across by hand using the move feature at the top of each page. What I would have done is moved the page 1949 to 1948, then changed the information on the new page. What I'm going to do now is to delete the 1949 page, as it doesn't contain any information now. Rupert 19:34, 8 January 2006 (CET)

Ta Mlj 19:47, 8 January 2006 (CET)

Hi ! I do enjoy teamworking ! Left a few comments on main page about style. What do you think

what a team

we make.

templates, and instructions

You can use a pair of noinclude tags to stop instructions from being copied into the resulting page. I think with levels of evidence, eitehr implicitly putting ht erules in, or hving a page disucssing them, to which each template has a link, is probably sensible in the long or very long run, for consistency and maintainability. Midgley 23:42, 11 February 2006 (CET)

Country boxes

If I'm going to be really honest, I preferred the boxes full width as they are meant to carry whole sections of text rather than a little soundbite. Have a peek at Help:Template to see how floating them right messes up the formatting! :-) --A.l.brown 09:44, 21 February 2006 (CET)

Also Registered medical practitioners look odd. --A.l.brown 12:35, 21 February 2006 (CET)

MRI Physics

Wow! Rather good. Midgley 11:53, 11 March 2006 (CET)

Image:CoagulationAndFibrolyticPathways.png

What a glorious diagram. High quality diagrams like this are something ganfyd is lacking in atm. Really good work, thanks. What package did you do it in, btw? Rupert 14:11, 17 April 2006 (CEST)

I'll second that. Awesome! --A.l.brown 19:42, 17 April 2006 (CEST)
The package is the commercial version of Chemsketch (9.0). It is best I have found for diagrams and molecular modelling and does it all in one. I did a trial of the free version 8.0 and was impressed enough over my experience with lots of drawing programs and a dabble with all the free molecular modelling programs that I could find that I forked out even though the free version did allow drawings to be used for educational purposes. Someone might try to say use a diagram like this for non-educational purposes after downloading it, and Ganfyd can do without hassle of someone moaning. The purchase is for my interest in Ganfyd...would never have done it otherwise as Chemsketch 8.0 features are not bad. Unhappily its Windows only...they stopped doing Linux version at 5.0. Mlj 20:33, 17 April 2006 (CEST)

BiochemistryBox

Trying this out on Chlorhexidine. Although the initial <div> command stipulates 40% width, after adding Hibiscrub to {{2}}, something has caused the IUPAC name to spread right across the table (despite me having added manual spaces to break up the IUPAC name). I don't know if it is just my browser and can't work out why the template stuggles with wrapping long words (esp. the IUPAC names).

Second thing: is it worth creating a separate ChemistryBox rather than BiochemistryBox for stuff like chlorhexidine, ethanol, etc. as the links to protein information are not applicable. Mark ong 17:18, 18 April 2006 (CEST)

BiochemistryBox is doing odd things

See Liothyronine. Seems to be working for other things. I cannot even begin to understand the complexities of such an advanced template I'm afraid! --A.l.brown 11:54, 30 April 2006 (BST)

I am such a spanner. Why didn't I notice that? --A.l.brown 18:43, 30 April 2006 (BST)
A present from Rupert (Talk) 21:23, 30 April 2006 (BST).
Thanks guys for great work. The problem for other readers was that spaces are not parsed in URLs. Adam has run up a <replace this=" " with="_">Mary had a little lamb</replace> will change Mary had a little lamb to Mary_had_a_little_lamb converter that we have not fully tested yet but it looks useful and Rupert has found a definite working solution using {{#urlencode:<string>}} and an interesting function indexing into template variables as far as I can see that reads{{#replace:(__0__)}}. What a team Mlj 22:35, 30 April 2006 (BST)

Upload if you want

Do whatever you want. We will write protect ganfyd once the upgrade starts, so you don't need to worry about courrputing anything. Pictures don't take up much database room, and what's another file on top of the tons we have already? So feel free! Rupert (Talk) 16:44, 7 May 2006 (BST)

Enantiomer

Just wondered if you could explain a little more clearly what you mean by "in the rat r-omeprazole is metabolised relatively safely, in man its s-omeprazole and in the dog it does not matter" and if you have more information about the toxicity of dextro amino acids—I did a really quick google search but couldn't find anything. Rupert (Talk) 21:01, 8 May 2006 (BST) Ah-Rupert: the first point could have cost Astra-Zenica billions if they had assumed what happened in rats happened in man (makes those animals rights lobbists who only want us to experiment on ourselves happy however) so I had better clarify and as for the second its rather old knowledge so I chased a recent literature quote for you

Hum Gene Ther. 1998 Jan 20;9(2):185-93. 
   Induction of cytotoxic oxidative stress by D-alanine in brain tumor cells expressing Rhodotorula gracilis D-amino acid oxidase: a cancer gene therapy strategy.
   Stegman LD, Zheng H, Neal ER, Ben-Yoseph O, Pollegioni L, Pilone MS, Ross BD.
   Department of Biological Chemistry, University of Michigan, Ann Arbor 48109, USA.
    Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS) generated in the stereoselective deamination of D-amino acids catalyzed by D-amino acid oxidase (DAAO). H2O2 readily crosses cellular membranes and damages DNA, proteins, and lipids. The scarcity of DAAO substrates in mammalian organisms and its co-localization with catalase in the peroxisomal matrix suggested that the cytotoxicity of ROS could be harnessed by administration of D-amino acids to tumor cells ectopically expressing DAAO in the cytoplasm. To evaluate this hypothesis, the cDNA encoding the highly active DAAO from the red yeast Rhodotorula gracilis was mutated to remove the carboxy-terminal peroxisomal targeting sequence. A clonal line of 9L glioma cells stably transfected with this construct (9Ldaao17) was found to synthesize active R. gracilis DAAO. Exposure of 9Ldaao17 cells to D-alanine resulted in cytotoxicity at concentrations that were nontoxic to parental 9L cells. Depletion of cellular glutathione further sensitized 9Ldaao17 cells to D-alanine (D-Ala). This result, combined with stimulation of pentose phosphate pathway activity and the production of extracellular H2O2 by 9Ldaao17 cells incubated with D-alanine implicates oxidative stress as the mediator of cytotoxicity. These results demonstrate that expression of R. gracilis DAAO in tumor cells confers chemosensitivity to D-alanine that could be exploited as a novel cancer gene therapy paradigm. 
Mlj 22:08, 8 May 2006 (BST)
Excellent stuff. Thanks very much. The box which explains the R/S +/- L/D enatiomer terminology is great too. Rupert (Talk) 22:43, 8 May 2006 (BST)
Interesting stuff above. Thanks for the edits to Artificial induction of immunity, I was whisked off to go swimming. I think it is a useful overview, and anticipate a more techncial fork than the one that aros on WP from it. Midgley 19:50, 21 May 2006 (BST)

Prodigy screwed subject box

Is this config, or the inability of another NHS org to keep a page/grammar/system/search people use static or incorporate it into their next spasm yet again?

http://www.prodigy.nhs.uk/errorpages/filenotfound.aspx?404_http://www.prodigy.nhs.uk/portal/search/advancedsearch.aspx,chickungunya

Midgley 10:53, 13 July 2006 (BST)

  • Prodigy still works. It just doesn't like hard spaces in passed strings-most data bases can cope. I haven't got around to see if the parsing functions I asked for, allow me to write special what if logic for Prodigy, mainly because I heard that its NHS license was under threat by DoH financial melt down so didn't know if it would remain free to all, and so be worth my debugging...and asking Rupert or Adam to do some php work if it doesn't work with my best efforts! Its simplier to pass chickungunya_fever as the variable, and I have logic that copes with this.Mlj 22:36, 13 July 2006 (BST)

Sysops & bureaucrats

I assume you were tring to give User:Manville the ability to delete pages. That's fine but you need sysop permission to do that. Although bureaucrat is a "higher level" in the sense that it can confer sysop and bureaucrat status on others, it does not enable the sysop abilities for that user (although I suppose they could enable it themselves.) Rupert (Talk) 21:51, 2 September 2006 (BST)

Ah. I see what you were trying to do from User talk:Manville. I will investigate why uploading is restricted. I'm sure that shouldn't be the case. Rupert (Talk) 21:54, 2 September 2006 (BST)
All sorted. Rupert (Talk) 22:02, 2 September 2006 (BST)


Copyright

Thanks for taking the time to spell the issue of copyright out for me. Perhaps this should be given it's own page? --Jb 17:19, 22 September 2006 (BST)

Ok I have.The most annoying thing is that most assume Yank conceptions of copyright when actually our associations with Europe mean the right of authors is held more strongly over here in UK. Peter Pan is the only simple copyright situation in the UK-Long may GOS florishMlj 23:14, 22 September 2006 (BST)

References extension

Thanks for your email. Hope you're well. I did get your comments on the references extension code. I can't actually put them to use them though until I have internet access on my own computer, as naturally the PMID cache on it doesn't have any test cases that don't work, or I would have already fixed them before the last release. The Internet's being installed on Monday. —Rupert (Talk) 10:37, 30 September 2006 (BST)

Nice work with bleeding risk

Great page - we need pages that focus on problems we have and things we do, and that is a good one. Midgley 23:31, 1 October 2006 (BST)

Yes it's really really nice. —Rupert (Talk) 09:56, 2 October 2006 (BST)

Chemistry Template

The template doesn't like the [a] in the IUPAC name for DHEA. Even if the square bracket problem is solved, there's still the problem that the template is designed to search both common name and IUPAC name. Makes complete sense for most chemical, but a problem with super-long IUPAC names. Mark ong 00:46, 17 October 2006 (BST)

Mark its all solvable I think, I just haven't got around to it. Mlj 21:20, 17 October 2006 (BST)

Periodic Table

Whew! Well done on finishing it - don't think I would have had the patience. Mark ong

Ha...you never truly finish anything on a wiki...but fit for purpose I think Mlj 10:05, 26 November 2006 (GMT)

Anticoagulation

Anticoagulation Material is v good, I did some rearranging. The tight control of 2-2.5 may need more emphasis, and a table of targets will probably appear. The latter could be made much more complex than the usual 2d table since we are not a print medium, but the underlying infromation may be sparse. eg a 3d table/block giving targets for minimum risk by age range? Midgley 15:53, 28 November 2006 (GMT)

Hi

Hi Michael, could you check your DnUK inbox! Ta. --A.l.brown 21:16, 24 January 2007 (GMT)

Ball view - molecular modellling software

http://www.ballview.org/ There is a Debian package, one for Ubuntu, and for those who like alternative operating systems, one for something called XP. It has pretty pictures. Midgley 09:57, 26 January 2007 (GMT)

Good cruise?

Welcome back then. Midgley 09:27, 26 February 2007 (UTC) ...stressed my health somewhat with the viral outbreak on board!!! Mlj 21:29, 26 February 2007 (UTC)

ECG history

Liked your contribution(s) on the ligated coronary arteries in dogs. I missed that on http://www.ecglibrary.com/ecghist.html but it is reading contributions such as this that usually prompts a further attack on the library! ... Have just read Fred Smith's 1918 article which was reproduced in 2004 in the Annals of Non-invasive Electrocardiography. Interestingly the accounts of the ECG changes focus on the T wave. In particular the (what we now call) hyperacute changes seen in the first few hours where the height of the T wave increases then becomes inverted then returns to normal or inverted position after a few days. It is similar to the description in man by Harold Pardee in 1920 so it seems that the literature at that time focussed on T wave changes only and not ST segment changes as well. Einthoven did not discuss "segments" the decade before but they are certainly discussed in other papers as intervals or spaces between the deflections. OK ... this has prompted further research. Thanks! Deanjenkins Bank Holiday Monday April 9th 2007

Chemistry images

Thanks very much for illustrating my articles. Adds lots to them!--Max 23:32, 18 April 2007 (BST)


By the way, how did you create or find these molecular layout diagrams? Are they created using Jumbo? --Max 23:38, 18 April 2007 (BST)

Many thanks for the explanation. I was a Classicist before entering Medicine. --Max 07:24, 20 April 2007 (BST)

Would you be able to produce molecular diagrams for my Trans and Cis articles, please? Thanks very much. --Max 20:54, 17 May 2007 (BST) Great job! Thanks. --Max 16:58, 18 May 2007 (BST)

PMID

Just wanted to say thanks again for all your help with PMID. I thought it was beyond repair, but you have done it! —Rupert (Talk) 12:52, 8 May 2007 (BST)

Not sure that now I have learnt some php5 (in sort of a day) its all good, as now I feel motivated to convert some of my old javascript client side scripts relevant to medicine in to php server side scripts for Ganfyd if some one gives me upload access to the calculator directory/partition. Mlj 20:09, 8 May 2007 (BST)

Christmas Hero

Congratulations on having the most number of edits for Christmas Day 2007!! --MoLE 08:37, 26 December 2007 (UTC)

Thanks & Happy New Year

Thanks for clarifying rules/templates Mlj. I'll only bring my own work across then.--Pierre 21:15, 3 January 2008 (UTC)

Blimey, you've been busy, Mlj!

I haven't counted the number of edits you've made over the weekend, but some of them are quite substantial (and excellent)! --Penglish 09:17, 7 January 2008 (UTC)

Tattoo

Thanks very much for improving this page! --Penglish 15:17, 2 July 2008 (BST)


Dear Adam, Penglish, mlj and Midgley,

I'm writing to you all with my 'RUK editorial' hat on. RUK is the journal of RemedyUK, and has a circulation of around 2000 copies atm. I am hoping to write a piece about medical wikis, especially ganfyd.org, following last months mention of the US site, medpedia. I would be grateful if any of you would be willing to take part in an email interview, asking a few questions about ganfyd.org, your involvement, and how you think medical wikis will influence the medical profession.

If you would be happy to take part, please email me, fishgoth at gmail.com

Best wishes,

Fishy aka Stephen O'Hanlon

Thanks for editorial help :¬)

I have looked over and (I hope) learned from your actions. --Tom 14:53, 10 January 2009 (UTC)

Thanks from me, too, for tweaking the citations at NHS_and_private_care. --Penglish 17:28, 25 March 2009 (UTC)


http://www.ganfyd.org/index.php?title=Clock_test&action=history Is that WRT ability to drive? ...No everything. Cheers Mlj 21:38, 19 June 2009 (UTC)

acetominophen and vaccination

Good catch, thanks for making that update. --Penglish 10:20, 20 October 2009 (UTC)

(Experience of) Incorporating EBM principles into a collaborative online textbook

sounds to me like a plausible response to the email reproduced below which was sent to the evidence based healthcare list recently.

The July 2012 newsletter of the International Society for Evidence-based Health Care is now available at the Society's Website:

http://www.isehc.net/?page_id=7

If you are interested in submitting an article for the January ISEHC newsletter – an editorial, a teaching tip or exercise, an EBM resource review, a regional report, or an original research or viewpoint piece, please email one of the editors:

Paul Glasziou - Paul_Glasziou@bond.edu.au

Gordon Guyatt - guyatt@mcmaster.ca

Jason Busse - j.busse@rogers.com


If you have a desire for the recognition due you for doing it then in your copious free time you might be tempted? I suffer from not having done it, not knowing much about it and not being very copious, 2 of which are credible excuses. Midgley 09:32, 3 August 2012 (BST)

NHS England; anonymity

Great work on NHS England Mlj!

I hope that you'll continue to feel able to contribute to ganfyd - see Good Medical Practice#Impact of this guidance on ganfyd.

--Penglish 16:25, 3 April 2013 (BST)

It will be a shame for my family if all my NHS retirement pot goes to the test case against the GMC. However deemed unlikely as hardly anonymous. If GMC bothers to put mlj into google combined with a few key worlds from my profile they will find my name according to their records in all the official NHS paperwork in public domain that over the years has minuted my bureaucratic contributions to committee work  :-) Mlj 23:51, 3 April 2013 (BST)

Thank you!

...for improving the CPR page. --Penglish 15:37, 7 July 2014 (BST)


Thanks, again!

...for improving the microcephaly page. --Penglish 18:11, 31 January 2016 (UTC)

Thanks for your work on the "Systems under pressure" page!

It's really good - thank you. --Penglish 00:11, 2 April 2018 (BST)