Anti-diuretic hormone

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rINN: Vasopressin
Other Names
ADH, antidiuretic hormone, anti-diuretic hormone, Pitressin®
Pharmacological Information
Pharmacology Images
Vasopressin Molecule
Web information on Vasopressin
Mechanism of Action
  • Acts on aquaporins in collecting ducts
  • Multiple receptors eg
    • Vasopressin V1b receptor (V1bR)
    • Vasopressin V3 receptor (AVPR V3)
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Other Wikis
Wikipedia on Anti-diuretic hormone (Less technical, ? quality control)

Anti-diuretic hormone(ADH) is also known as vasopressin (VP). It is a polypeptide hormone released from supraoptic nucleus of hypothalamus. Travels down and stored in posterior pituitary.

Acts on aquaporins in collecting ducts in renal medulla to increase free water uptake.

Excess vasopressin (ADH) leads to the Syndrome of inappropriate antidiuretic hormone release (SIADH)

Deficiency of vasopressin (ADH) leads to Diabetes insipidus

Synthetic hormones are available:

Secretion inhibited by alcohol