- Acts on aquaporins in collecting ducts
- Multiple receptors eg
- Vasopressin V1b receptor (V1bR)
- Vasopressin V3 receptor (AVPR V3)
Acts on aquaporins in collecting ducts in renal medulla to increase free water uptake.
Excess vasopressin (ADH) leads to the Syndrome of inappropriate antidiuretic hormone release (SIADH)
Deficiency of vasopressin (ADH) leads to Diabetes insipidus
Synthetic hormones are available:
Secretion inhibited by alcohol
- Peri-operatively in haemophilia
- As vasopressor in CPR - no apparent advantage over adrenaline on current data.
- ↑ Aung K, Htay T. Vasopressin for cardiac arrest: a systematic review and meta-analysis. Archives of internal medicine 2005;165:17-24. (Direct link – subscription may be required.)
- ↑ Wyer PC, Perera P, Jin Z, Zhou Q, Cook DJ, Walter SD, et al. Vasopressin or epinephrine for out-of-hospital cardiac arrest. Annals of emergency medicine 2006;48:86-97. (Direct link – subscription may be required.)