Ximelagatran

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rINN: Ximelagatran
Other Names
Exanta®, Exarta®
Pharmacological Information
Web information on Ximelagatran
NHS Evidence on Ximelagatran
DrugBank on Ximelagatran
Metabolism & Interactions
Metabolised to melagatran
Mechanism of Action
Thrombin inhibitor
Other Issues for Ximelagatran
Hepatotoxic
Relevant Clinical Literature
Pubmed on Ximelagatran
RCT with Ximelagatran
Systematic reviews of Ximelagatran
Ximelagatran in N Eng J Med, Lancet, JAMA, BMJ
Ximelagatran in Cochrane Collaboration
TRIP Database on Ximelagatran
Google Scholar on Ximelagatran
Bandolier on Ximelagatran
UK Guidance
Nice Guidance on Ximelagatran

BNF-registration required
BNF for children-registration required

UK directory of medicines
UK Medicine Guide (eg pictures of capsules)
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Prodigy Guidance on Ximelagatran
Regulatory Literature
UK SPCs of medicines with marketing authorisation
EMEA search
FDA search
Other Literature
PubChem on Ximelagatran
CTD (Comparative Toxicogenomics Database) link
ChemIndustry.com link
Protein Structural Information
Biological Information (GenomeNet)
Protein Knowledgebase (UniProtKB)
Please read pharmacological data limitations
Other Wikis
Medpedia on Ximelagatran (Less technical, good quality control)
Wikipedia on Ximelagatran (Less technical, ? quality control)

Very clinically efficious as an oral anticoagulant in clinical trials but caused too much unpredictable hepatotoxicity in real world.

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