Zidovudine

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Contents

Introduction

Zidovudine is commonly referred to as AZT. It is the archetypal anti-HIV drug. It was developed in the mid-1980s to treat AIDS patients.

Clinical Use

Developed for the treatment of HIV.

Indications

Administration

Oral

Clinical Issues

The phenomenal replication rate of HIV and its replicative infidelity mean that resistance to AZT monotherapy in the 1980s was soon detected. This is true for all anti-HIV drugs.

Contra-indications

Cautions and Interactions

Side effects

Special advice

Pharmacology

Structural analog of thymidine.

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