The SLC30A8 gene at 8q24.11 encodes the 369 amino acid propeptide for zinc transporter-8. This is a zinc-efflux transporter expressed in pancreatic beta-cells. The zinc binding portion is histidine-rich. Auto antibodies are found against it in some patients with type 1 diabetes mellitus. It is known that variants influence susceptibility to type 2 diabetes mellitus and that it can also be expressed on lymphocytes.