Ziprasidone

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Contents

Introduction

Licensed by the FDA. Not marketed in UK.

Clinical Use

Indications

Administration

Clinical Issues

Contra-indications

  • QT prolongation
  • Recent myocardial infarction

Cautions and Interactions

Side effects

Atypical antipsychotic clinical issues

Contra-indications

Dementia is probably a contraindication for any antipsychotic (fair evidence for increased mortality in long term use) and has an interesting medicolegal potential as it is unclear if following recent changes in datasheets (SPCs) and warnings from the regulatory authorities (eg FDA) any manufacturer will share liability for out of licence use (off license) use in newly commenced patients. In the UK an urgent review is taking place as of 2008.

Cautions

Side-effects

Special advice

  • ECG monitoring required

Pharmacology

  • cyclodextrin used to increase solubility
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