Zollinger-Ellison Syndrome (ZE syndrome) is caused by excess gastrin production by gastrinomas. Gastrinomas are usually located in the pancreas and duodenum, but can metastatise, usually to the liver. They can also produce parathyroid hormone and calcitonin.
- Upper gastro-intestinal peptic ulceration - classic cause of multiple resistant peptic ulceration (90%)
- Abdominal pain
- Upper gastro-intestinal haemorrhage
- Diarrhoea (can be steatorrhea) (40%)
- Fatigue and weakness
- High dose proton pump inhibitors
- Somatostatin and its analogues.
- Surgical resection (improves outcome)