Zollinger-Ellison syndrome

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Zollinger-Ellison Syndrome (ZE syndrome) is caused by excess gastrin production by gastrinomas. Gastrinomas are usually located in the pancreas and duodenum, but can metastatise, usually to the liver. They can also produce parathyroid hormone and calcitonin.



LogoWarningBox4.pngIt is pointless measuring gastrin levels if a patient is on (or has recently been on) a proton pump inhibitor - you can get levels in the thousands
  • Upper gastro-intestinal peptic ulceration - classic cause of multiple resistant peptic ulceration (90%)
    • Abdominal pain
    • Upper gastro-intestinal haemorrhage
  • Diarrhoea (can be steatorrhea) (40%)
  • Fatigue and weakness



Zollinger and Ellison described the syndrome in 1955