Zotepine

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Contents

Introduction

Clinical Use

Indications

Administration

Oral from 25mg o bd in adults to max. 100mg tds (75mg bd in elderly)

Clinical Issues

Contra-indications

  • Intoxication acutely with CNS depressants
  • Acute gout
  • Renal stones
  • Breast feeding

Cautions and Interactions

  • As for anticholinergic drugs

Side effects

  • Anticholinergic

Atypical antipsychotic clinical issues

Contra-indications

Dementia is probably a contraindication for any antipsychotic (fair evidence for increased mortality in long term use) and has an interesting medicolegal potential as it is unclear if following recent changes in datasheets (SPCs) and warnings from the regulatory authorities (eg FDA) any manufacturer will share liability for out of licence use (off license) use in newly commenced patients. In the UK an urgent review is taking place as of 2008.

Cautions

Side-effects

Special advice

  • ECG required before and with each dose titration
  • ECr required before and with each dose titration

Pharmacology

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